You're not locked in to the standard 960 grid that's built into Webflow. Here's how to use any custom 12-column grid you you might prefer:
That's it. You can drop webflow's column tool into your new containers and they will divide along your column guides. If you want to hide the grid (especially when you're ready to publish), just remove the body class. You can also hide it in the Page backgrounds panel, but you'll have to re-center it if you decide to show it again.
Note: you'll have to develop separate grids for smaller viewports. I didn't do that in this example, but you'd just install different backgrounds on the custom container for whichever viewports you want to customize.
Note2: Unlike Webflow's native grids, these are in the background. I realize that's not quite as useful, but it works fine for me. If you really want an overlay grid, you could create a Div block that sits on top of everything—but I think it would get in the way of accessing page elements for most workflows.